Product Data Sheet
GABAA receptor agent 2 TFA
Catalog No. A66775
GABAA receptor agent 2 TFA is a potent GABAA receptor antagonist that exhibits an IC50 of 24 nM in human α1β2γ2 GABAA-expressing tsA201 cells and a Ki of 28 nM in rat GABAA receptors. This compound selectively inhibits GABAA receptor activity without affecting four human GABA transporters (hGAT-1, hBGT-1, hGAT-2, and hGAT-3). It serves as a valuable tool for studying GABAA receptor-mediated pathways and exploring therapeutic interventions in neurological disorders.
Chemical Information
| Catalog Num | A66775 |
|---|---|
| M. Wt | 433.42 |
| Formula | C22H22F3N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1781880-44-1 |
| Synonyms | |
| SMILES | ON1N=CC(C2CCNCC2)=C1C3=CC(C4=CC=CC=C4)=CC=C3.OC(C(F)(F)F)=O |
Biological Activity
| Description | GABAA receptor agent 2 TFA is a potent GABAA receptor antagonist that exhibits an IC50 of 24 nM in human α1β2γ2 GABAA-expressing tsA201 cells and a Ki of 28 nM in rat GABAA receptors. This compound selectively inhibits GABAA receptor activity without affecting four human GABA transporters (hGAT-1, hBGT-1, hGAT-2, and hGAT-3). It serves as a valuable tool for studying GABAA receptor-mediated pathways and exploring therapeutic interventions in neurological disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
