Product Data Sheet
(-)-JM-1232
Catalog No. A66790
(-)-JM-1232 is a ligand for GABA A receptors that binds to the benzodiazepine binding site, leading to pronounced analgesic effects. This compound has shown significant efficacy in preclinical models, with CI50 values of 2.96 mg/kg for acute thermal stimuli, 3.06 mg/kg for mechanically induced pain, and 2.27 mg/kg for visceral pain. The potent analgesic properties of (-)-JM-1232 make it a valuable tool for research focused on pain mechanisms and the development of analgesic therapies.
Chemical Information
| Catalog Num | A66790 |
|---|---|
| M. Wt | 389.49 |
| Formula | C24H27N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1013427-48-9 |
| Synonyms | MR04A3 |
| SMILES | O=C(N1CCN(CC1)C)C[C@@H]2C3=C(C=C4C(CCC4)=C3)C(N2C5=CC=CC=C5)=O |
Biological Activity
| Description | (-)-JM-1232 is a ligand for GABA A receptors that binds to the benzodiazepine binding site, leading to pronounced analgesic effects. This compound has shown significant efficacy in preclinical models, with CI50 values of 2.96 mg/kg for acute thermal stimuli, 3.06 mg/kg for mechanically induced pain, and 2.27 mg/kg for visceral pain. The potent analgesic properties of (-)-JM-1232 make it a valuable tool for research focused on pain mechanisms and the development of analgesic therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
