Product Data Sheet
Anxiolytic/nonsedative agent-1
Catalog No. A66800
Anxiolytic/Nonsedative Agent-1 is a potent GABAA receptor agonist demonstrating selective affinity for various benzodiazepine receptors in bovine brain membranes, with inhibition constants (Kis) of 14, 121, and 239 nM for α1β2γ2, α2β2γ2, and α5β3γ2 subtypes, respectively. This compound exhibits selective efficacy for the α2 subunit in vitro and displays anxioselective effects in vivo, making it a valuable tool for research into anxiety-related disorders and potential therapeutics.
Chemical Information
| Catalog Num | A66800 |
|---|---|
| M. Wt | 337.33 |
| Formula | C18H15N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 355022-97-8 |
| Synonyms | |
| SMILES | O=C(N[C@@H](C1=CC=CC=C1)C)C(C2=CNC3=C2C=C([N+]([O-])=O)C=C3)=O |
Biological Activity
| Description | Anxiolytic/Nonsedative Agent-1 is a potent GABAA receptor agonist demonstrating selective affinity for various benzodiazepine receptors in bovine brain membranes, with inhibition constants (Kis) of 14, 121, and 239 nM for α1β2γ2, α2β2γ2, and α5β3γ2 subtypes, respectively. This compound exhibits selective efficacy for the α2 subunit in vitro and displays anxioselective effects in vivo, making it a valuable tool for research into anxiety-related disorders and potential therapeutics. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
