Product Data Sheet
CGP55845
Catalog No. A66841
CGP55845 is a potent and selective antagonist of the GABAB receptor, effectively blocking agonist binding. With an IC50 value of 5 nM, it demonstrates significant inhibition of GABA and glutamate release. The compound exhibits a high affinity for the GABAB receptor, with an apparent Kd of 30 nM. CGP55845 is comparable in potency to 100 μM CGP 35348 for reversing the inhibitory effects of (R)-(-)-baclofen, making it a valuable tool for research into GABAergic signaling and related physiological functions.
Chemical Information
| Catalog Num | A66841 |
|---|---|
| M. Wt | 402.25 |
| Formula | C18H22Cl2NO3P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 150175-54-5 |
| Synonyms | |
| SMILES | O=P(CC1=CC=CC=C1)(C[C@@H](O)CN[C@H](C2=CC=C(Cl)C(Cl)=C2)C)O |
Biological Activity
| Description | CGP55845 is a potent and selective antagonist of the GABAB receptor, effectively blocking agonist binding. With an IC50 value of 5 nM, it demonstrates significant inhibition of GABA and glutamate release. The compound exhibits a high affinity for the GABAB receptor, with an apparent Kd of 30 nM. CGP55845 is comparable in potency to 100 μM CGP 35348 for reversing the inhibitory effects of (R)-(-)-baclofen, making it a valuable tool for research into GABAergic signaling and related physiological functions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
