Product Data Sheet
Lesogaberan napadisylate
Catalog No. A66863
Lesogaberan napadisylate is a potent and selective agonist of the GABAB receptor, exhibiting an EC50 of 8.6 nM for human recombinant receptors. It demonstrates strong affinity for rat GABAB and GABAA receptors, with Kis values of 5.1 nM and 1.4 μM, respectively. This compound effectively inhibits transient lower esophageal sphincter relaxation, making it relevant for research into gastrointestinal disorders and neuromodulation.
Chemical Information
| Catalog Num | A66863 |
|---|---|
| M. Wt | 349.31 |
| Formula | C13H17FNO5PS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 477956-38-0 |
| Synonyms | AZD-3355 napadisylate |
| SMILES | O=S(C1=CC=C2C=CC=CC2=C1)(O)=O.O=P(C[C@H](F)CN)O |
Biological Activity
| Description | Lesogaberan napadisylate is a potent and selective agonist of the GABAB receptor, exhibiting an EC50 of 8.6 nM for human recombinant receptors. It demonstrates strong affinity for rat GABAB and GABAA receptors, with Kis values of 5.1 nM and 1.4 μM, respectively. This compound effectively inhibits transient lower esophageal sphincter relaxation, making it relevant for research into gastrointestinal disorders and neuromodulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
