Product Data Sheet
GABAA receptor modulator-5
Catalog No. A66902
GABAA receptor modulator-5 is a selective modulator of the GABA A receptor, demonstrating EC50 values of 56 nM and 10 nM for the α1β2γ2 and α4β3δ subtypes, respectively. This compound exhibits favorable pharmacokinetic properties in rat models and shows a threshold dose of 23.3 μmol/kg for loss of rollover reflex (LORR), indicating slight toxicity. GABAA receptor modulator-5 has potential applications in the research of postpartum depression and may contribute to therapeutic strategies targeting GABAergic pathways.
Chemical Information
| Catalog Num | A66902 |
|---|---|
| M. Wt | 514.61 |
| Formula | C28H36F2N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3021554-08-2 |
| Synonyms | |
| SMILES | C[C@@]12[C@](CC[C@@H]2C(CN3C=NN(C4=CC(F)=NC(F)=C4)C3=O)=O)([H])[C@]5([H])CC[C@]6([H])C[C@@](O)(C)CC[C@]6([H])[C@@]5([H])CC1 |
Biological Activity
| Description | GABAA receptor modulator-5 is a selective modulator of the GABA A receptor, demonstrating EC50 values of 56 nM and 10 nM for the α1β2γ2 and α4β3δ subtypes, respectively. This compound exhibits favorable pharmacokinetic properties in rat models and shows a threshold dose of 23.3 μmol/kg for loss of rollover reflex (LORR), indicating slight toxicity. GABAA receptor modulator-5 has potential applications in the research of postpartum depression and may contribute to therapeutic strategies targeting GABAergic pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
