Product Data Sheet
Tiagabine-d5 hydrochloride
Catalog No. A66921
Tiagabine-d5 hydrochloride is a deuterium-labeled derivative of Tiagabine hydrochloride, primarily functioning as a selective GABA reuptake inhibitor. It exhibits potent anticonvulsant properties, with IC50 values of 67 nM, 446 nM, and 182 nM for [3H]GABA uptake in synaptosomes, neurons, and glial cells, respectively. This stable isotope form is valuable for pharmacokinetic studies and metabolic profiling in research applications focused on GABAergic neurotransmission and seizure disorders.
Chemical Information
| Catalog Num | A66921 |
|---|---|
| M. Wt | 417.04 |
| Formula | C20H21D5ClNO2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1253297-72-1 |
| Synonyms | NO050328-d5 hydrochloride; NO328-d5 hydrochloride; TGB-d5 hydrochloride |
| SMILES | OC([C@H](CCC1)CN1C([2H])([2H])C([2H])([2H])/C([2H])=C(C2=C(C=CS2)C)\C3=C(C=CS3)C)=O.Cl |
Biological Activity
| Description | Tiagabine-d5 hydrochloride is a deuterium-labeled derivative of Tiagabine hydrochloride, primarily functioning as a selective GABA reuptake inhibitor. It exhibits potent anticonvulsant properties, with IC50 values of 67 nM, 446 nM, and 182 nM for [3H]GABA uptake in synaptosomes, neurons, and glial cells, respectively. This stable isotope form is valuable for pharmacokinetic studies and metabolic profiling in research applications focused on GABAergic neurotransmission and seizure disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
