Product Data Sheet
PNU-107484A
Catalog No. A66960
PNU-107484A is a selective GABAA receptor ligand with distinct activity across various α isoform subtypes. It functions as a positive allosteric modulator for the α1β2γ2 subtype, enhancing GABA-induced chloride currents, while exhibiting inhibitory effects on the α3β2γ2 and α6β2γ2 subtypes. The compound demonstrates half-maximal inhibitory concentrations of 3.1 μM for α1β2γ2, 4.2 μM for α3β2γ2, and 3.5 μM for α6β2γ2. PNU-107484A serves as a valuable tool for exploring the physiological implications of different GABAA receptor α isoform subtypes in research settings.
Chemical Information
| Catalog Num | A66960 |
|---|---|
| M. Wt | 358.87 |
| Formula | C18H23ClN6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 200266-76-8 |
| Synonyms | |
| SMILES | CN1C2=NC(N3CCCC3)=NC(N4CCCC4)=C2C5=C1C=CN=C5.Cl |
Biological Activity
| Description | PNU-107484A is a selective GABAA receptor ligand with distinct activity across various α isoform subtypes. It functions as a positive allosteric modulator for the α1β2γ2 subtype, enhancing GABA-induced chloride currents, while exhibiting inhibitory effects on the α3β2γ2 and α6β2γ2 subtypes. The compound demonstrates half-maximal inhibitory concentrations of 3.1 μM for α1β2γ2, 4.2 μM for α3β2γ2, and 3.5 μM for α6β2γ2. PNU-107484A serves as a valuable tool for exploring the physiological implications of different GABAA receptor α isoform subtypes in research settings. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
