Product Data Sheet
THIP-d4
Catalog No. A66961
THIP-d4, a deuterium-labeled derivative of THIP (Gaboxadol), selectively targets extrasynaptic GABAA receptors (eGABARs) with a reported EC50 of 13 μM for δ-GABAAR. This compound demonstrates strong potentiation of GABAA-mediated currents in layer 2/3 neurons while having no effect on miniature inhibitory postsynaptic currents (IPSCs). THIP-d4 is valuable for research into sleep disorders and other neurological conditions related to GABAergic signaling.
Chemical Information
| Catalog Num | A66961 |
|---|---|
| M. Wt | 144.16 |
| Formula | C6H4D4N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2748778-97-2 |
| Synonyms | Gaboxadol-d4 |
| SMILES | O=C1C2=C(ON1)CNC([2H])([2H])C2([2H])[2H] |
Biological Activity
| Description | THIP-d4, a deuterium-labeled derivative of THIP (Gaboxadol), selectively targets extrasynaptic GABAA receptors (eGABARs) with a reported EC50 of 13 μM for δ-GABAAR. This compound demonstrates strong potentiation of GABAA-mediated currents in layer 2/3 neurons while having no effect on miniature inhibitory postsynaptic currents (IPSCs). THIP-d4 is valuable for research into sleep disorders and other neurological conditions related to GABAergic signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
