Product Data Sheet
ZD 9379 sodium
Catalog No. A67011
ZD 9379 sodium acts as a competitive antagonist at the glycine-binding site of the NMDA receptor, exhibiting an IC50 value of 75 nM for the glutamate site. This compound inhibits glycine binding, mitigating excitotoxicity and demonstrating therapeutic potential in conditions such as acute ischemic stroke. ZD 9379 sodium reduces the frequency of cortical spreading depression, decreases infarct volume, and enhances neurological function in preclinical mouse models, making it a valuable tool for research in neuroprotection and stroke mechanisms.
Chemical Information
| Catalog Num | A67011 |
|---|---|
| M. Wt | 406.77 |
| Formula | C19H15ClN3NaO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 170142-29-7 |
| Synonyms | |
| SMILES | O=C1C2=C(C(NN1C3=C(C=C(OC)C=C3)C)=O)NC4=C(C=CC(Cl)=C4)C2=O.[Na] |
Biological Activity
| Description | ZD 9379 sodium acts as a competitive antagonist at the glycine-binding site of the NMDA receptor, exhibiting an IC50 value of 75 nM for the glutamate site. This compound inhibits glycine binding, mitigating excitotoxicity and demonstrating therapeutic potential in conditions such as acute ischemic stroke. ZD 9379 sodium reduces the frequency of cortical spreading depression, decreases infarct volume, and enhances neurological function in preclinical mouse models, making it a valuable tool for research in neuroprotection and stroke mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
