Product Data Sheet
Orphenadrine
Catalog No. A67080
Orphenadrine is a skeletal muscle relaxant that acts as an NMDA antagonist, primarily inhibiting the binding of [3H]MK-801 to the PCP binding site of the NMDA receptor. This compound exhibits a range of biological activities including antiparkinsonian, antihistaminic, antitremor, antispasmodic, and analgesic effects. Additionally, Orphenadrine has been shown to induce oxidative stress through CAR nuclear translocation and may have implications in pro-tumor activities. It also demonstrates neuroprotective properties by safeguarding rat cerebellar granule cells from 3-NPA-induced cytotoxicity, suggesting potential therapeutic applications in neurodegenerative diseases associated with NMDA receptor overactivation.
Chemical Information
| Catalog Num | A67080 |
|---|---|
| M. Wt | 269.38 |
| Formula | C18H23NO |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 83-98-7 |
| Synonyms | (±)-Orphenadrine |
| SMILES | CN(C)CCOC(C1=C(C)C=CC=C1)C2=CC=CC=C2 |
Biological Activity
| Description | Orphenadrine is a skeletal muscle relaxant that acts as an NMDA antagonist, primarily inhibiting the binding of [3H]MK-801 to the PCP binding site of the NMDA receptor. This compound exhibits a range of biological activities including antiparkinsonian, antihistaminic, antitremor, antispasmodic, and analgesic effects. Additionally, Orphenadrine has been shown to induce oxidative stress through CAR nuclear translocation and may have implications in pro-tumor activities. It also demonstrates neuroprotective properties by safeguarding rat cerebellar granule cells from 3-NPA-induced cytotoxicity, suggesting potential therapeutic applications in neurodegenerative diseases associated with NMDA receptor overactivation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
