Product Data Sheet
Nitromemantine
Catalog No. A67239
Nitromemantine is a selective NMDAR antagonist that acts through a dual mechanism, effectively blocking ion channels while also modulating receptor function via nitric oxide and redox pathways. It demonstrates significant therapeutic potential in rodent models of cerebral infarction, particularly in targeting ischemic neurons under hypoxic conditions. With an IC50 of 2.4 μM for inhibiting NMDA-induced current, Nitromemantine is a valuable tool for investigating the mechanisms and treatment strategies related to cerebral ischemic stroke.
Chemical Information
| Catalog Num | A67239 |
|---|---|
| M. Wt | 268.35 |
| Formula | C14H24N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 765890-91-3 |
| Synonyms | NitroSynapsin; YQW-036; NMI-6979 |
| SMILES | CCC1(C2)CC3(CC)CC2(N)CC(C3)(O[N+]([O-])=O)C1 |
Biological Activity
| Description | Nitromemantine is a selective NMDAR antagonist that acts through a dual mechanism, effectively blocking ion channels while also modulating receptor function via nitric oxide and redox pathways. It demonstrates significant therapeutic potential in rodent models of cerebral infarction, particularly in targeting ischemic neurons under hypoxic conditions. With an IC50 of 2.4 μM for inhibiting NMDA-induced current, Nitromemantine is a valuable tool for investigating the mechanisms and treatment strategies related to cerebral ischemic stroke. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
