Product Data Sheet
R-(+)-EU-1180-453
Catalog No. A67241
R-(+)-EU-1180-453 is a positive allosteric modulator that targets NMDA receptors containing GluN2C and GluN2D subunits, demonstrating a pEC50 value of 5.5 for both rat receptor subtypes. This compound enhances the potency of glutamate, amplifying receptor responses to agonists while acting selectively on receptors co-bound with both necessary co-agonists. R-(+)-EU-1180-453 is suitable for research into neurological conditions, including Alzheimer's disease, Parkinson's disease, epilepsy, and neuropathic pain.
Chemical Information
| Catalog Num | A67241 |
|---|---|
| M. Wt | 380.42 |
| Formula | C22H21FN2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2488764-06-1 |
| Synonyms | |
| SMILES | C(OC1=CC=C(OC)C=C1)[C@H]2C=3N(CC(=O)N2CC4=CC(F)=CC=C4)C=CC3 |
Biological Activity
| Description | R-(+)-EU-1180-453 is a positive allosteric modulator that targets NMDA receptors containing GluN2C and GluN2D subunits, demonstrating a pEC50 value of 5.5 for both rat receptor subtypes. This compound enhances the potency of glutamate, amplifying receptor responses to agonists while acting selectively on receptors co-bound with both necessary co-agonists. R-(+)-EU-1180-453 is suitable for research into neurological conditions, including Alzheimer's disease, Parkinson's disease, epilepsy, and neuropathic pain. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
