Product Data Sheet
YM928
Catalog No. A67245
YM928 is a noncompetitive antagonist of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. This compound effectively inhibits AMPA receptor-mediated neurotoxicity in primary rat hippocampal cultures with an IC50 of 2 μM. Additionally, YM928 blocks AMPA-induced intracellular calcium influx (IC50 of 3 μM) and antagonizes AMPA-induced inward currents (IC50 of 1 μM). It holds potential for research into various neurological disorders.
Chemical Information
| Catalog Num | A67245 |
|---|---|
| M. Wt | 303.77 |
| Formula | C14H10ClN3OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 190842-36-5 |
| Synonyms | |
| SMILES | O=C1N=C(SC2=NC=CC=C12)N(C)C3=CC=C(C=C3)Cl |
Biological Activity
| Description | YM928 is a noncompetitive antagonist of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. This compound effectively inhibits AMPA receptor-mediated neurotoxicity in primary rat hippocampal cultures with an IC50 of 2 μM. Additionally, YM928 blocks AMPA-induced intracellular calcium influx (IC50 of 3 μM) and antagonizes AMPA-induced inward currents (IC50 of 1 μM). It holds potential for research into various neurological disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
