Product Data Sheet
CP-283097
Catalog No. A67263
CP-283097 is a selective NR2B subtype NMDA antagonist that acts competitively to inhibit [³H]CP-101,606 binding, with an IC50 of 18 nM. This compound effectively blocks NR2B-mediated currents (IC50 = 206 nM) while demonstrating minimal impact on NR2A and NR2C receptors, highlighting its specificity. CP-283097 possesses strong central nervous system permeability and has shown in vivo efficacy in preclinical models. It is suitable for research applications targeting neurological disorders associated with excessive NMDA receptor activation.
Chemical Information
| Catalog Num | A67263 |
|---|---|
| M. Wt | 355.43 |
| Formula | C21H25NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 138047-56-0 |
| Synonyms | |
| SMILES | O[C@@H]1[C@H](N2CCC(O)(CC2)CC3=CC=CC=C3)COC4=CC(O)=CC=C41 |
Biological Activity
| Description | CP-283097 is a selective NR2B subtype NMDA antagonist that acts competitively to inhibit [³H]CP-101,606 binding, with an IC50 of 18 nM. This compound effectively blocks NR2B-mediated currents (IC50 = 206 nM) while demonstrating minimal impact on NR2A and NR2C receptors, highlighting its specificity. CP-283097 possesses strong central nervous system permeability and has shown in vivo efficacy in preclinical models. It is suitable for research applications targeting neurological disorders associated with excessive NMDA receptor activation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
