Product Data Sheet
D-AP4
Catalog No. A67275
D-AP4 (D-2-Amino-4-phosphonobutyric acid) is a broad-spectrum NMDA receptor antagonist, functioning as a phosphono analogue of glutamate. This compound also acts as an agonist for a quisqualate-sensitized AP6 site in the hippocampus. D-AP4 effectively inhibits AMPA receptor-mediated 57Co2+ influx in cultured cerebellar granule cells, with an IC50 value of approximately 100 μM. This makes D-AP4 a valuable tool for investigating glutamatergic signaling and its implications in neurobiology and related research applications.
Chemical Information
| Catalog Num | A67275 |
|---|---|
| M. Wt | 183.10 |
| Formula | C4H10NO5P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 78739-01-2 |
| Synonyms | D-APB; D-2-Amino-4-phosphonobutyric acid |
| SMILES | O=C(O)[C@H](N)CCP(O)(O)=O |
Biological Activity
| Description | D-AP4 (D-2-Amino-4-phosphonobutyric acid) is a broad-spectrum NMDA receptor antagonist, functioning as a phosphono analogue of glutamate. This compound also acts as an agonist for a quisqualate-sensitized AP6 site in the hippocampus. D-AP4 effectively inhibits AMPA receptor-mediated 57Co2+ influx in cultured cerebellar granule cells, with an IC50 value of approximately 100 μM. This makes D-AP4 a valuable tool for investigating glutamatergic signaling and its implications in neurobiology and related research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
