Product Data Sheet
BPAM363
Catalog No. A67318
BPAM363 is an orally active, selective positive allosteric modulator (PAM) of AMPA receptors (AMPARs). It effectively enhances AMPAR activity in both human and rat models, exhibiting an EC2x value of 0.96 μM in rat embryonic cortical primary neurons. Additionally, BPAM363 promotes the upregulation of brain-derived neurotrophic factor (BDNF) protein expression in rat primary cortical neuronal cultures and increases AMPA-mediated excitatory postsynaptic responses in rat and mouse models. This compound is valuable for researching cognitive disorders and related neurological conditions.
Chemical Information
| Catalog Num | A67318 |
|---|---|
| M. Wt | 293.17 |
| Formula | C10H10Cl2N2O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1204572-46-2 |
| Synonyms | |
| SMILES | O=S1(NCN(C2=CC(Cl)=C(C=C21)Cl)C3CC3)=O |
Biological Activity
| Description | BPAM363 is an orally active, selective positive allosteric modulator (PAM) of AMPA receptors (AMPARs). It effectively enhances AMPAR activity in both human and rat models, exhibiting an EC2x value of 0.96 μM in rat embryonic cortical primary neurons. Additionally, BPAM363 promotes the upregulation of brain-derived neurotrophic factor (BDNF) protein expression in rat primary cortical neuronal cultures and increases AMPA-mediated excitatory postsynaptic responses in rat and mouse models. This compound is valuable for researching cognitive disorders and related neurological conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
