Product Data Sheet
Indantadol hydrochloride
Catalog No. A67393
Indantadol hydrochloride is a potent, non-selective NMDA antagonist that also exhibits monoamine oxidase (MAO) inhibitory activity. It effectively inhibits the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM, and completely abolishes NMDA-induced dopamine release. Additionally, Indantadol hydrochloride demonstrates neuroprotective properties with an ED₅₀ of 35 μM, and displays valuable anticonvulsant and analgesic effects, making it relevant for studies in pain hypersensitivity and seizure disorders.
Chemical Information
| Catalog Num | A67393 |
|---|---|
| M. Wt | 226.70 |
| Formula | C11H15ClN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 202914-18-9 |
| Synonyms | CHF-3381 |
| SMILES | O=C(CNC1CC2=C(C1)C=CC=C2)N.Cl |
Biological Activity
| Description | Indantadol hydrochloride is a potent, non-selective NMDA antagonist that also exhibits monoamine oxidase (MAO) inhibitory activity. It effectively inhibits the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM, and completely abolishes NMDA-induced dopamine release. Additionally, Indantadol hydrochloride demonstrates neuroprotective properties with an ED₅₀ of 35 μM, and displays valuable anticonvulsant and analgesic effects, making it relevant for studies in pain hypersensitivity and seizure disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
