Product Data Sheet
YM-244769 dihydrochloride
Catalog No. A67493
YM-244769 dihydrochloride is a selective and orally active inhibitor of the Na+/Ca2+ exchanger (NCX), particularly targeting the NCX3 isoform. With IC50 values of 18 nM for NCX3, it effectively suppresses outward NCX currents, facilitating studies on calcium signaling in neurons. This compound demonstrates protective effects against hypoxia/reoxygenation-induced damage in SH-SY5Y neuronal cells, making it a valuable reagent for research in neuroprotection and related fields. Additionally, it has been shown to influence urinary output and electrolyte excretion in mouse models, contributing to its utility in pharmacological studies.
Chemical Information
| Catalog Num | A67493 |
|---|---|
| M. Wt | 516.39 |
| Formula | C26H24Cl2FN3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1780390-65-9 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4.Cl.Cl |
Biological Activity
| Description | YM-244769 dihydrochloride is a selective and orally active inhibitor of the Na+/Ca2+ exchanger (NCX), particularly targeting the NCX3 isoform. With IC50 values of 18 nM for NCX3, it effectively suppresses outward NCX currents, facilitating studies on calcium signaling in neurons. This compound demonstrates protective effects against hypoxia/reoxygenation-induced damage in SH-SY5Y neuronal cells, making it a valuable reagent for research in neuroprotection and related fields. Additionally, it has been shown to influence urinary output and electrolyte excretion in mouse models, contributing to its utility in pharmacological studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
