Product Data Sheet
AN317
Catalog No. A67608
AN317 is a selective agonist for the α6β2-containing nicotinic acetylcholine receptor (nAChR), exhibiting Ki values of 6.2 nM for the α6/α3β2β3 receptor and 4.1 nM for the α4β2 receptor. This compound effectively induces dopamine release in rat striatum synaptosomes and enhances dopaminergic neuronal activity in the substantia nigra. Additionally, AN317 demonstrates neuroprotective effects against dopamine neurotoxin MPP+ and possesses favorable pharmacokinetic properties, including the ability to cross the blood-brain barrier. Research applications include studies in neuropharmacology and the exploration of mechanisms underlying dopaminergic signaling.
Chemical Information
| Catalog Num | A67608 |
|---|---|
| M. Wt | 217.31 |
| Formula | C13H19N3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 946074-35-7 |
| Synonyms | |
| SMILES | CN(C(CCC1)C2)C1CN2C3=CC=CN=C3 |
Biological Activity
| Description | AN317 is a selective agonist for the α6β2-containing nicotinic acetylcholine receptor (nAChR), exhibiting Ki values of 6.2 nM for the α6/α3β2β3 receptor and 4.1 nM for the α4β2 receptor. This compound effectively induces dopamine release in rat striatum synaptosomes and enhances dopaminergic neuronal activity in the substantia nigra. Additionally, AN317 demonstrates neuroprotective effects against dopamine neurotoxin MPP+ and possesses favorable pharmacokinetic properties, including the ability to cross the blood-brain barrier. Research applications include studies in neuropharmacology and the exploration of mechanisms underlying dopaminergic signaling. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
