Product Data Sheet
CP-601932
Catalog No. A67636
CP-601932 is a high-affinity partial agonist targeting the α3β4 nicotinic acetylcholine receptor (nAChR), with a Ki of 21 nM and an EC50 of approximately 3 μM. It exhibits comparable binding affinity at the α4β2 nAChR, while displaying significantly lower affinity for the α6 and α7 subtypes. CP-601932 is demonstrated to selectively reduce ethanol consumption and operant self-administration behaviors following prolonged exposure, suggesting its potential utility in addiction research. Furthermore, this compound effectively penetrates the central nervous system, enabling comprehensive studies of its effects on neurobiology.
Chemical Information
| Catalog Num | A67636 |
|---|---|
| M. Wt | 227.23 |
| Formula | C12H12F3N |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 357425-68-4 |
| Synonyms | (1S,5R)-CP-601927 |
| SMILES | FC(F)(C1=CC=C([C@@H]2C[C@H]3CNC2)C3=C1)F |
Biological Activity
| Description | CP-601932 is a high-affinity partial agonist targeting the α3β4 nicotinic acetylcholine receptor (nAChR), with a Ki of 21 nM and an EC50 of approximately 3 μM. It exhibits comparable binding affinity at the α4β2 nAChR, while displaying significantly lower affinity for the α6 and α7 subtypes. CP-601932 is demonstrated to selectively reduce ethanol consumption and operant self-administration behaviors following prolonged exposure, suggesting its potential utility in addiction research. Furthermore, this compound effectively penetrates the central nervous system, enabling comprehensive studies of its effects on neurobiology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
