Product Data Sheet
RO5126946
Catalog No. A67671
RO5126946 is a selective allosteric potentiator of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 0.06 μM for human α7 nAChR. This compound enhances synaptic transmission and positively modulates GABAergic responses by increasing peak current and elevating the frequency of spontaneous inhibitory postsynaptic currents while preserving receptor recovery from desensitization. RO5126946 is valuable for investigating cognitive deficits associated with neurodegenerative disorders such as Alzheimer's disease and psychiatric conditions including schizophrenia, as it augments the cognitive-enhancing effects of nicotine without detracting from its efficacy.
Chemical Information
| Catalog Num | A67671 |
|---|---|
| M. Wt | 408.90 |
| Formula | C19H21ClN2O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1137233-79-4 |
| Synonyms | |
| SMILES | N(C(=O)C1=C(OC)C=CC(Cl)=C1)[C@H]2[C@@H](C2(C)C)C3=CC=C(S(N)(=O)=O)C=C3 |
Biological Activity
| Description | RO5126946 is a selective allosteric potentiator of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 0.06 μM for human α7 nAChR. This compound enhances synaptic transmission and positively modulates GABAergic responses by increasing peak current and elevating the frequency of spontaneous inhibitory postsynaptic currents while preserving receptor recovery from desensitization. RO5126946 is valuable for investigating cognitive deficits associated with neurodegenerative disorders such as Alzheimer's disease and psychiatric conditions including schizophrenia, as it augments the cognitive-enhancing effects of nicotine without detracting from its efficacy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
