Product Data Sheet
A-424274
Catalog No. A67672
A-424274 is a positive allosteric modulator of the α4β2 neuronal nicotinic acetylcholine receptor. This compound enhances the potency and efficacy of various nicotinic acetylcholine receptor agonists, making it a valuable tool in pain management research. In preclinical studies, co-administration of A-424274 with an α4β2 positive allosteric modulator has been shown to significantly improve the analgesic effects of ABT-594, demonstrating its potential for enhancing therapeutic outcomes in pain relief.
Chemical Information
| Catalog Num | A67672 |
|---|---|
| M. Wt | 225.29 |
| Formula | C14H15N3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1335145-56-6 |
| Synonyms | |
| SMILES | [H][C@]12CN(C3=CC4=CC=CC=C4N=C3)C[C@@]1([H])NC2 |
Biological Activity
| Description | A-424274 is a positive allosteric modulator of the α4β2 neuronal nicotinic acetylcholine receptor. This compound enhances the potency and efficacy of various nicotinic acetylcholine receptor agonists, making it a valuable tool in pain management research. In preclinical studies, co-administration of A-424274 with an α4β2 positive allosteric modulator has been shown to significantly improve the analgesic effects of ABT-594, demonstrating its potential for enhancing therapeutic outcomes in pain relief. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
