Product Data Sheet
TC299423
Catalog No. A67684
TC299423 is a selective and potent agonist of the α6β2 and α4β2 nicotinic acetylcholine receptors (nAChRs) with significant anxiolytic and antinociceptive properties. This orally active compound effectively penetrates the blood-brain barrier and primarily targets the α6β2 nAChRs, which are associated with the anxiolytic effects of nicotine. Research indicates that TC299423 induces reward-related behaviors in α6L90’S hypersensitive mice and stimulates dopamine release without inhibiting nicotine self-administration in rats. Its pharmacological profile suggests potential applications in the study of addiction and Parkinson's disease.
Chemical Information
| Catalog Num | A67684 |
|---|---|
| M. Wt | 189.26 |
| Formula | C11H15N3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1975146-56-5 |
| Synonyms | |
| SMILES | C1(/C2=CN=CN=C2)=C\CCNCCC1 |
Biological Activity
| Description | TC299423 is a selective and potent agonist of the α6β2 and α4β2 nicotinic acetylcholine receptors (nAChRs) with significant anxiolytic and antinociceptive properties. This orally active compound effectively penetrates the blood-brain barrier and primarily targets the α6β2 nAChRs, which are associated with the anxiolytic effects of nicotine. Research indicates that TC299423 induces reward-related behaviors in α6L90’S hypersensitive mice and stimulates dopamine release without inhibiting nicotine self-administration in rats. Its pharmacological profile suggests potential applications in the study of addiction and Parkinson's disease. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
