Product Data Sheet
18β-Glycyrrhetyl-3-O-sulfate
Catalog No. A67779
18β-Glycyrrhetyl-3-O-sulfate is a potent inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), exhibiting an IC50 value of 0.10 µM in rat kidney microsomes. As the principal metabolite of Glycyrrhetinic acid, this compound serves as a substrate for organic anion transporters OAT1 and OAT3. Its anti-inflammatory properties make it a valuable tool for studying pseudohyperaldosteronism and related conditions in biochemical and pharmacological research.
Chemical Information
| Catalog Num | A67779 |
|---|---|
| M. Wt | 550.75 |
| Formula | C30H46O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 10251-38-4 |
| Synonyms | Glycyrrhetic acid 3-O-hydrogen sulfate |
| SMILES | C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@@](C)(C4)C(O)=O)C)=CC([C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)OS(=O)(O)=O)C)([H])CC2)C)=O)C |
Biological Activity
| Description | 18β-Glycyrrhetyl-3-O-sulfate is a potent inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), exhibiting an IC50 value of 0.10 µM in rat kidney microsomes. As the principal metabolite of Glycyrrhetinic acid, this compound serves as a substrate for organic anion transporters OAT1 and OAT3. Its anti-inflammatory properties make it a valuable tool for studying pseudohyperaldosteronism and related conditions in biochemical and pharmacological research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
