Product Data Sheet
JNJ-47965567
Catalog No. A67886
JNJ-47965567 is a high-affinity, selective antagonist of the P2X7 receptor, exhibiting centrally permeable properties with pKis of 7.9 for human P2X7 and 8.7 for rat P2X7. This compound is instrumental in investigating the role of central P2X7 in rodent models, providing insights into its involvement in various CNS pathophysiological conditions. JNJ-47965567 is valuable for studies aimed at elucidating the molecular mechanisms underlying neurological disorders.
Chemical Information
| Catalog Num | A67886 |
|---|---|
| M. Wt | 488.64 |
| Formula | C28H32N4O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1428327-31-4 |
| Synonyms | |
| SMILES | O=C(C1=CC=CN=C1SC2=CC=CC=C2)NCC3(N4CCN(C5=CC=CC=C5)CC4)CCOCC3 |
Biological Activity
| Description | JNJ-47965567 is a high-affinity, selective antagonist of the P2X7 receptor, exhibiting centrally permeable properties with pKis of 7.9 for human P2X7 and 8.7 for rat P2X7. This compound is instrumental in investigating the role of central P2X7 in rodent models, providing insights into its involvement in various CNS pathophysiological conditions. JNJ-47965567 is valuable for studies aimed at elucidating the molecular mechanisms underlying neurological disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
