Product Data Sheet
JNJ-55308942
Catalog No. A67888
JNJ-55308942 is a selective P2X7 antagonist with high affinity and significant brain penetration. It effectively inhibits the P2X7 receptor, demonstrating IC50 values of 10 nM for human and 15 nM for rat P2X7, along with corresponding Ki values of 7.1 nM and 2.9 nM. This compound is orally bioavailable and has been shown to block the release of IL-1β from adult rodent brain tissue, making it a valuable tool for investigating neuroinflammatory processes and related therapeutic applications.
Chemical Information
| Catalog Num | A67888 |
|---|---|
| M. Wt | 425.32 |
| Formula | C17H12F5N7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2166558-11-6 |
| Synonyms | |
| SMILES | O=C(C1=C(F)C(C(F)(F)F)=NC=C1)N2[C@@H](C)CC(N(C3=NC=C(F)C=N3)N=N4)=C4C2 |
Biological Activity
| Description | JNJ-55308942 is a selective P2X7 antagonist with high affinity and significant brain penetration. It effectively inhibits the P2X7 receptor, demonstrating IC50 values of 10 nM for human and 15 nM for rat P2X7, along with corresponding Ki values of 7.1 nM and 2.9 nM. This compound is orally bioavailable and has been shown to block the release of IL-1β from adult rodent brain tissue, making it a valuable tool for investigating neuroinflammatory processes and related therapeutic applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
