Product Data Sheet
P2X3 antagonist 34
Catalog No. A67895
P2X3 antagonist 34 is a selective and orally active antagonist targeting the P2X3 homotrimeric receptor, demonstrating IC50 values of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors, respectively. This compound exhibits reduced activity against P2X2/3 heterotrimeric receptors, indicating a favorable selectivity profile. Its significant anti-tussive properties make P2X3 antagonist 34 a valuable tool for research in pain and respiratory conditions.
Chemical Information
| Catalog Num | A67895 |
|---|---|
| M. Wt | 456.49 |
| Formula | C24H26F2N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2417288-67-4 |
| Synonyms | |
| SMILES | O=C(OC)N1C[C@@H](CCC1)CC2=C(N=C3C=C(C=CN32)C)C4=C(C=C(C=C4F)C(NC)=O)F |
Biological Activity
| Description | P2X3 antagonist 34 is a selective and orally active antagonist targeting the P2X3 homotrimeric receptor, demonstrating IC50 values of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors, respectively. This compound exhibits reduced activity against P2X2/3 heterotrimeric receptors, indicating a favorable selectivity profile. Its significant anti-tussive properties make P2X3 antagonist 34 a valuable tool for research in pain and respiratory conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
