Product Data Sheet
Lu AF27139
Catalog No. A67898
Lu AF27139 is a selective antagonist of the P2X7 receptor, exhibiting potent inhibitory activity with IC50 values of 12 nM and 2.4 nM for human and rat receptors, respectively. Additionally, it demonstrates effective inhibition in mouse, human, and rat models with Kis of 22, 54, and 13 nM. Due to its favorable pharmacokinetic profile, including oral activity and CNS penetration, Lu AF27139 is a valuable tool for investigating central nervous system diseases.
Chemical Information
| Catalog Num | A67898 |
|---|---|
| M. Wt | 497.92 |
| Formula | C21H19ClF3N5O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2097117-06-9 |
| Synonyms | |
| SMILES | ClC(C=C1)=CC=C1[C@H](N2CCOCC2)CNC(C3=C(C(F)(F)F)N=C(C4=NC=CC=N4)S3)=O |
Biological Activity
| Description | Lu AF27139 is a selective antagonist of the P2X7 receptor, exhibiting potent inhibitory activity with IC50 values of 12 nM and 2.4 nM for human and rat receptors, respectively. Additionally, it demonstrates effective inhibition in mouse, human, and rat models with Kis of 22, 54, and 13 nM. Due to its favorable pharmacokinetic profile, including oral activity and CNS penetration, Lu AF27139 is a valuable tool for investigating central nervous system diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
