Product Data Sheet
RO-3
Catalog No. A67906
RO-3 is a potent orally active antagonist of the P2X3 and P2X2/3 receptors, exhibiting pIC50 values of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. This compound demonstrates selectivity for P2X3 and P2X2/3, with IC50 values exceeding 10 μM against all other functional P2X receptor homomultimers, including P2X1, P2X2, P2X4, P2X5, and P2X7. RO-3 is valuable for research focused on pain pathways and chronic pain conditions due to its specific receptor interactions.
Chemical Information
| Catalog Num | A67906 |
|---|---|
| M. Wt | 302.37 |
| Formula | C16H22N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1026582-88-6 |
| Synonyms | |
| SMILES | NC1=NC=C(CC2=CC(OC)=C(OC)C=C2C(C)C)C(N)=N1 |
Biological Activity
| Description | RO-3 is a potent orally active antagonist of the P2X3 and P2X2/3 receptors, exhibiting pIC50 values of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. This compound demonstrates selectivity for P2X3 and P2X2/3, with IC50 values exceeding 10 μM against all other functional P2X receptor homomultimers, including P2X1, P2X2, P2X4, P2X5, and P2X7. RO-3 is valuable for research focused on pain pathways and chronic pain conditions due to its specific receptor interactions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
