Product Data Sheet
AF-353 hydrochloride
Catalog No. A67912
AF-353 hydrochloride is a potent and selective antagonist of the P2X3 and P2X2/3 receptors, exhibiting a pIC50 of 8.0 for both human and rat P2X3 and a pIC50 of 7.3 for human P2X2/3. This compound is notable for its oral bioavailability, making it suitable for in vivo studies. AF-353 hydrochloride is primarily utilized in research applications focused on pain modulation and the study of purinergic signaling pathways.
Chemical Information
| Catalog Num | A67912 |
|---|---|
| M. Wt | 436.68 |
| Formula | C14H18ClIN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 927887-18-1 |
| Synonyms | Ro-4 hydrochloride |
| SMILES | IC1=C(OC)C=C(C(C)C)C(OC2=CN=C(N)N=C2N)=C1.Cl |
Biological Activity
| Description | AF-353 hydrochloride is a potent and selective antagonist of the P2X3 and P2X2/3 receptors, exhibiting a pIC50 of 8.0 for both human and rat P2X3 and a pIC50 of 7.3 for human P2X2/3. This compound is notable for its oral bioavailability, making it suitable for in vivo studies. AF-353 hydrochloride is primarily utilized in research applications focused on pain modulation and the study of purinergic signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
