Product Data Sheet
JNJ-54166060
Catalog No. A67920
JNJ-54166060 is a potent and selective antagonist of the P2X7 receptor, exhibiting IC50 values of 4 nM for the human, 115 nM for the rat, and 72 nM for the mouse P2X7 receptor. This compound modulates the purinergic signaling pathway, influencing processes such as inflammation and cell death. JNJ-54166060 is valuable for research applications related to autoimmune diseases, neuroinflammation, and other conditions where P2X7 receptor modulation is of interest.
Chemical Information
| Catalog Num | A67920 |
|---|---|
| M. Wt | 438.81 |
| Formula | C20H15ClF4N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1627900-41-7 |
| Synonyms | |
| SMILES | O=C(C1=CC=CC(C(F)(F)F)=C1Cl)N2CCC3=C(N=CN3C4=NC=C(F)C=C4)[C@H]2C |
Biological Activity
| Description | JNJ-54166060 is a potent and selective antagonist of the P2X7 receptor, exhibiting IC50 values of 4 nM for the human, 115 nM for the rat, and 72 nM for the mouse P2X7 receptor. This compound modulates the purinergic signaling pathway, influencing processes such as inflammation and cell death. JNJ-54166060 is valuable for research applications related to autoimmune diseases, neuroinflammation, and other conditions where P2X7 receptor modulation is of interest. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
