Product Data Sheet
GSK1370319A
Catalog No. A67930
GSK1370319A is a selective inhibitor of the human P2X7 receptor, demonstrating an IC50 of 474 nM and a Ki of 176 nM. This compound effectively inhibits the production of interleukin-1 beta (IL-1β), decreases the generation of reactive oxygen species (ROS), and enhances macrophage survival rates. GSK1370319A is applicable in research related to inflammatory bowel disease and the broader study of inflammatory processes.
Chemical Information
| Catalog Num | A67930 |
|---|---|
| M. Wt | 301.17 |
| Formula | C13H14Cl2N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1001389-31-6 |
| Synonyms | |
| SMILES | C(NCC1=C(Cl)C=C(Cl)C=C1)(=O)[C@H]2N(C)C(=O)CC2 |
Biological Activity
| Description | GSK1370319A is a selective inhibitor of the human P2X7 receptor, demonstrating an IC50 of 474 nM and a Ki of 176 nM. This compound effectively inhibits the production of interleukin-1 beta (IL-1β), decreases the generation of reactive oxygen species (ROS), and enhances macrophage survival rates. GSK1370319A is applicable in research related to inflammatory bowel disease and the broader study of inflammatory processes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
