Product Data Sheet
α,β-Methylene-ATP dilithium
Catalog No. A67938
α,β-Methylene-ATP dilithium is a selective agonist for P2X1 and P2X3 receptors, capable of crossing the blood-brain barrier. It induces a reflex pressor response by activating these receptors in peripheral muscles and the central locus coeruleus, with effects that can be inhibited by the P2X antagonist PPADS. Additionally, it stimulates noradrenergic neurons in the central locus coeruleus, contributing to antinociceptive effects that can be reduced by DSP-4. This compound is valuable for investigating the mechanisms underlying neuropathic pain, cardiovascular reflex regulation, and central nervous system analgesia.
Chemical Information
| Catalog Num | A67938 |
|---|---|
| M. Wt | 519.09 |
| Formula | C11H18Li2N5O12P3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 104809-20-3 |
| Synonyms | |
| SMILES | OP(OP(CP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O)=O)(O)=O)(O)=O.[Li].[Li] |
Biological Activity
| Description | α,β-Methylene-ATP dilithium is a selective agonist for P2X1 and P2X3 receptors, capable of crossing the blood-brain barrier. It induces a reflex pressor response by activating these receptors in peripheral muscles and the central locus coeruleus, with effects that can be inhibited by the P2X antagonist PPADS. Additionally, it stimulates noradrenergic neurons in the central locus coeruleus, contributing to antinociceptive effects that can be reduced by DSP-4. This compound is valuable for investigating the mechanisms underlying neuropathic pain, cardiovascular reflex regulation, and central nervous system analgesia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
