Product Data Sheet
NF449
Catalog No. A67944
NF449 is a potent antagonist of the P2X1 receptor, demonstrating IC50 values of 0.28 nM for rP2X1, 0.69 nM for rP2X1+5, and 120 nM for P2X2+3. It selectively inhibits Gsα coupling, suppressing GTP[γS] binding to Gsα-s and diminishing adenylyl cyclase activity. This compound is crucial for research applications involving the modulation of purinergic signaling and studies related to cardiovascular and inflammatory conditions.
Chemical Information
| Catalog Num | A67944 |
|---|---|
| M. Wt | 1329.24 |
| Formula | C41H32N6O29S8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 389142-38-5 |
| Synonyms | |
| SMILES | O=C(NC1=CC(C(NC2=CC=C(S(=O)(O)=O)C=C2S(=O)(O)=O)=O)=CC(C(NC3=CC=C(S(=O)(O)=O)C=C3S(=O)(O)=O)=O)=C1)NC4=CC(C(NC5=CC=C(S(=O)(O)=O)C=C5S(=O)(O)=O)=O)=CC(C(NC6=CC=C(S(=O)(O)=O)C=C6S(=O)(O)=O)=O)=C4 |
Biological Activity
| Description | NF449 is a potent antagonist of the P2X1 receptor, demonstrating IC50 values of 0.28 nM for rP2X1, 0.69 nM for rP2X1+5, and 120 nM for P2X2+3. It selectively inhibits Gsα coupling, suppressing GTP[γS] binding to Gsα-s and diminishing adenylyl cyclase activity. This compound is crucial for research applications involving the modulation of purinergic signaling and studies related to cardiovascular and inflammatory conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
