Product Data Sheet
Yoda2
Catalog No. A67949
Yoda2 (KC289) functions as a Piezo1 agonist with an EC50 of 150 nM, facilitating calcium ion elevation and nitric oxide-dependent relaxation. This compound induces vasodilation in mouse arterial and cavernous tissues. Additionally, Yoda2 is implicated in inhibiting glucocorticoid-induced osteoclast formation and bone resorptive activity, effectively reversing glucocorticoid-mediated bone density loss and structural deterioration. Its applications extend to research in areas such as hypertension and osteoporosis.
Chemical Information
| Catalog Num | A67949 |
|---|---|
| M. Wt | 435.39 |
| Formula | C16H9Cl2KN2O2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3081450-95-2 |
| Synonyms | KC289 |
| SMILES | O=C(O[K])C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1 |
Biological Activity
| Description | Yoda2 (KC289) functions as a Piezo1 agonist with an EC50 of 150 nM, facilitating calcium ion elevation and nitric oxide-dependent relaxation. This compound induces vasodilation in mouse arterial and cavernous tissues. Additionally, Yoda2 is implicated in inhibiting glucocorticoid-induced osteoclast formation and bone resorptive activity, effectively reversing glucocorticoid-mediated bone density loss and structural deterioration. Its applications extend to research in areas such as hypertension and osteoporosis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
