Product Data Sheet
Azetukalner
Catalog No. A67952
Azetukalner is a selective Kv7.2/Kv7.3 potassium channel activator, demonstrating an EC50 of 27 nM. This compound exhibits approximately four-fold selectivity for the Kv7.2/7.3 combination over Kv7.3/7.5 and Kv7.4 channels, with EC50 values of 94 nM and 113 nM, respectively. Azetukalner's specificity exceeds 100-fold for Kv7 channels when compared to other ion channels and receptors. This reagent is valuable for research focused on focal epilepsy.
Chemical Information
| Catalog Num | A67952 |
|---|---|
| M. Wt | 368.49 |
| Formula | C23H29FN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1009344-33-5 |
| Synonyms | XEN1101 |
| SMILES | O=C(CC(C)(C)C)NC1=C(C)C=C(N2CC3=CC=C(C=C3CC2)F)C=C1C |
Biological Activity
| Description | Azetukalner is a selective Kv7.2/Kv7.3 potassium channel activator, demonstrating an EC50 of 27 nM. This compound exhibits approximately four-fold selectivity for the Kv7.2/7.3 combination over Kv7.3/7.5 and Kv7.4 channels, with EC50 values of 94 nM and 113 nM, respectively. Azetukalner's specificity exceeds 100-fold for Kv7 channels when compared to other ion channels and receptors. This reagent is valuable for research focused on focal epilepsy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
