Product Data Sheet
2-PPA
Catalog No. A67955
2-PPA is a selective blocker of the TMEM175 lysosomal potassium and proton channel, inhibiting the pore to occlude ion permeation pathways. This compound enhances lysosomal macromolecule degradation and accelerates macropinocytosis, making it a valuable tool in cellular and molecular research. 2-PPA's ability to covalently bind to hepatic proteins further supports its potential in investigating cellular processes. Its applications extend to the study of Parkinson's disease, providing insights into lysosomal function and related pathologies.
Chemical Information
| Catalog Num | A67955 |
|---|---|
| M. Wt | 170.22 |
| Formula | C11H10N2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 21203-86-1 |
| Synonyms | |
| SMILES | NC1=CC(C2=CC=CC=C2)=NC=C1 |
Biological Activity
| Description | 2-PPA is a selective blocker of the TMEM175 lysosomal potassium and proton channel, inhibiting the pore to occlude ion permeation pathways. This compound enhances lysosomal macromolecule degradation and accelerates macropinocytosis, making it a valuable tool in cellular and molecular research. 2-PPA's ability to covalently bind to hepatic proteins further supports its potential in investigating cellular processes. Its applications extend to the study of Parkinson's disease, providing insights into lysosomal function and related pathologies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
