Product Data Sheet
ICA-27243
Catalog No. A67961
ICA-27243 is a selective and orally active opener of the KCNQ2/Q3 potassium channels, exhibiting an EC50 of 0.38 μM. This compound has demonstrated potent antiepileptic and anticonvulsant properties, making it valuable for neurological research. Additionally, it shows lower efficacy towards KCNQ4 and the KCNQ3/Q5 channels, highlighting its specificity. ICA-27243 is an important tool for investigating the role of KCNQ channels in neuronal excitability and related disorders.
Chemical Information
| Catalog Num | A67961 |
|---|---|
| M. Wt | 268.65 |
| Formula | C12H7ClF2N2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 325457-89-4 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(C(F)=C1)F)NC2=CC=C(N=C2)Cl |
Biological Activity
| Description | ICA-27243 is a selective and orally active opener of the KCNQ2/Q3 potassium channels, exhibiting an EC50 of 0.38 μM. This compound has demonstrated potent antiepileptic and anticonvulsant properties, making it valuable for neurological research. Additionally, it shows lower efficacy towards KCNQ4 and the KCNQ3/Q5 channels, highlighting its specificity. ICA-27243 is an important tool for investigating the role of KCNQ channels in neuronal excitability and related disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
