Product Data Sheet
BL-1249
Catalog No. A67965
BL-1249 is a selective opener of the TREK-1 (K2P2.1) and TREK-2 (K2P10.1) potassium channels, demonstrating potent activation with EC50 values of 5.5 μM and 8.0 μM, respectively. This compound effectively activates all members of the TREK subfamily while exhibiting no activity towards other K2P subfamilies. Notably, BL-1249 shows enhanced selectivity for bladder tissue, with an EC50 of 1.26 μM, compared to a higher EC50 of 21.0 μM in vascular tissue. The compound is valuable in research related to pain management and bladder function regulation.
Chemical Information
| Catalog Num | A67965 |
|---|---|
| M. Wt | 291.35 |
| Formula | C17H17N5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 18200-13-0 |
| Synonyms | |
| SMILES | C1(NC2=C3CCCCC3=CC=C2)=CC=CC=C1C4=NN=NN4 |
Biological Activity
| Description | BL-1249 is a selective opener of the TREK-1 (K2P2.1) and TREK-2 (K2P10.1) potassium channels, demonstrating potent activation with EC50 values of 5.5 μM and 8.0 μM, respectively. This compound effectively activates all members of the TREK subfamily while exhibiting no activity towards other K2P subfamilies. Notably, BL-1249 shows enhanced selectivity for bladder tissue, with an EC50 of 1.26 μM, compared to a higher EC50 of 21.0 μM in vascular tissue. The compound is valuable in research related to pain management and bladder function regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
