Product Data Sheet
ML 297
Catalog No. A67971
ML 297 is a potent and selective activator of GIRK1/2 channels, exhibiting an EC50 of 0.16 μM. This compound effectively crosses the blood-brain barrier, demonstrated by a brain-to-plasma ratio of 0.2 in murine models following intraperitoneal administration. ML 297 is under investigation for its potential therapeutic applications in the treatment of epilepsy.
Chemical Information
| Catalog Num | A67971 |
|---|---|
| M. Wt | 328.32 |
| Formula | C17H14F2N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1443246-62-5 |
| Synonyms | VU 0456810; CID 56642816 |
| SMILES | FC1=C(F)C=CC(NC(NC2=CC(C)=NN2C3=CC=CC=C3)=O)=C1 |
Biological Activity
| Description | ML 297 is a potent and selective activator of GIRK1/2 channels, exhibiting an EC50 of 0.16 μM. This compound effectively crosses the blood-brain barrier, demonstrated by a brain-to-plasma ratio of 0.2 in murine models following intraperitoneal administration. ML 297 is under investigation for its potential therapeutic applications in the treatment of epilepsy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
