Product Data Sheet
L17E
Catalog No. A67973
L17E is an attenuated cationic amphiphilic lytic peptide that facilitates the delivery of macromolecules, including proteins, antibodies, and DNA nanostructures. Its mechanism involves membrane insertion and cleavage via electrostatic interactions, promoting intracellular escape. The effectiveness of L17E is closely linked to the expression of KCNN4, encoding the calcium-activated potassium channel KCa3.1, and it enhances cellular uptake through the induction of micropinocytosis. Additionally, L17E can be optimized through dimerization and combined with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles, for improved performance in research applications.
Chemical Information
| Catalog Num | A67973 |
|---|---|
| M. Wt | 2859.42 |
| Formula | C134H220N38O31 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1898254-09-5 |
| Synonyms | |
| SMILES |
Biological Activity
| Description | L17E is an attenuated cationic amphiphilic lytic peptide that facilitates the delivery of macromolecules, including proteins, antibodies, and DNA nanostructures. Its mechanism involves membrane insertion and cleavage via electrostatic interactions, promoting intracellular escape. The effectiveness of L17E is closely linked to the expression of KCNN4, encoding the calcium-activated potassium channel KCa3.1, and it enhances cellular uptake through the induction of micropinocytosis. Additionally, L17E can be optimized through dimerization and combined with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles, for improved performance in research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
