Product Data Sheet
VU0134992 hydrochloride
Catalog No. A67982
VU0134992 hydrochloride is a selective blocker of the Kir4.1 potassium channel, exhibiting an IC50 of 0.97 µM. This compound demonstrates a nine-fold selectivity for homomeric Kir4.1 channels compared to Kir4.1/5.1 concatemeric channels, with an IC50 of 9 µM at -120 mV. Its unique profile makes it a valuable tool for investigating the physiological roles of Kir4.1 channels in various biological processes and potential therapeutic applications.
Chemical Information
| Catalog Num | A67982 |
|---|---|
| M. Wt | 447.84 |
| Formula | C20H32BrClN2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1052515-91-9 |
| Synonyms | |
| SMILES | O=C(NC1CC(C)(C)NC(C)(C)C1)COC2=CC=C(C(C)C)C=C2Br.[H]Cl |
Biological Activity
| Description | VU0134992 hydrochloride is a selective blocker of the Kir4.1 potassium channel, exhibiting an IC50 of 0.97 µM. This compound demonstrates a nine-fold selectivity for homomeric Kir4.1 channels compared to Kir4.1/5.1 concatemeric channels, with an IC50 of 9 µM at -120 mV. Its unique profile makes it a valuable tool for investigating the physiological roles of Kir4.1 channels in various biological processes and potential therapeutic applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
