Product Data Sheet
Eleclazine hydrochloride
Catalog No. A67987
Eleclazine hydrochloride is a selective inhibitor of the cardiac late sodium current, exhibiting an IC50 value of less than 1 μM, along with a weaker inhibitory effect on potassium current (IC50 approximately 14.2 μM). This compound demonstrates therapeutic potential by providing protection against autonomically induced atrial premature beats, repolarization alternans, heterogeneity, and atrial fibrillation in porcine models. Eleclazine hydrochloride is applicable in the study of cardiac arrhythmias and their underlying mechanisms.
Chemical Information
| Catalog Num | A67987 |
|---|---|
| M. Wt | 451.83 |
| Formula | C21H17ClF3N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1448754-43-5 |
| Synonyms | GS 6615 hydrochloride |
| SMILES | O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13.[H]Cl |
Biological Activity
| Description | Eleclazine hydrochloride is a selective inhibitor of the cardiac late sodium current, exhibiting an IC50 value of less than 1 μM, along with a weaker inhibitory effect on potassium current (IC50 approximately 14.2 μM). This compound demonstrates therapeutic potential by providing protection against autonomically induced atrial premature beats, repolarization alternans, heterogeneity, and atrial fibrillation in porcine models. Eleclazine hydrochloride is applicable in the study of cardiac arrhythmias and their underlying mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
