Product Data Sheet
ICA-105665
Catalog No. A67991
ICA-105665 is a potent opener of neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels. It effectively enhances potassium ion flow, making it relevant for research in neurological disorders, particularly in the context of seizure activity. Additionally, ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport with an IC50 of 311 μM, positioning it as a valuable tool for studying both central nervous system and hepatic physiological processes. Its ability to penetrate the blood-brain barrier further supports its utility in investigating antiseizure mechanisms.
Chemical Information
| Catalog Num | A67991 |
|---|---|
| M. Wt | 355.34 |
| Formula | C19H15F2N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2694728-63-5 |
| Synonyms | PF-04895162 |
| SMILES | O=C(NN1C(C2CC2)=NC3=C(C=CC(F)=C3)C1=O)CC4=CC=C(F)C=C4 |
Biological Activity
| Description | ICA-105665 is a potent opener of neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels. It effectively enhances potassium ion flow, making it relevant for research in neurological disorders, particularly in the context of seizure activity. Additionally, ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport with an IC50 of 311 μM, positioning it as a valuable tool for studying both central nervous system and hepatic physiological processes. Its ability to penetrate the blood-brain barrier further supports its utility in investigating antiseizure mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
