Product Data Sheet
Flindokalner
Catalog No. A67993
Flindokalner is a potassium channel modulator that positively influences all neuronal Kv7 channel subtypes expressed in HEK293 cells, alongside acting as a positive modulator of large conductance calcium-activated potassium channels (BKca). It exhibits negative modulatory activity at Kv7.1 channels with a Ki of 3.7 μM and also negatively modulates GABAA receptors. In vivo studies demonstrate its anxiolytic efficacy, making it a valuable reagent for research in neuropharmacology and the study of ion channel function.
Chemical Information
| Catalog Num | A67993 |
|---|---|
| M. Wt | 359.70 |
| Formula | C16H10ClF4NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 187523-35-9 |
| Synonyms | BMS-204352 |
| SMILES | O=C1NC2=C(C=CC(C(F)(F)F)=C2)[C@@]1(C3=CC(Cl)=CC=C3OC)F |
Biological Activity
| Description | Flindokalner is a potassium channel modulator that positively influences all neuronal Kv7 channel subtypes expressed in HEK293 cells, alongside acting as a positive modulator of large conductance calcium-activated potassium channels (BKca). It exhibits negative modulatory activity at Kv7.1 channels with a Ki of 3.7 μM and also negatively modulates GABAA receptors. In vivo studies demonstrate its anxiolytic efficacy, making it a valuable reagent for research in neuropharmacology and the study of ion channel function. |
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
