Product Data Sheet
ML252
Catalog No. A67995
ML252 is a selective inhibitor of the KCNQ2 (Kv7.2) ion channel, exhibiting an IC50 of 69 nM for KCNQ2, along with lower inhibitory effects on KCNQ1, KCNQ2/Q3, and KCNQ4. This compound also demonstrates inhibition of key Cytochrome P450 enzymes, including CYP1A2, CYP2C9, CYP3A4, and CYP2D6, with IC50 values ranging from 3.9 nM to 19.9 nM. ML252 is notable for its ability to penetrate the blood-brain barrier, making it a valuable tool for investigating neuronal function and related disorders.
Chemical Information
| Catalog Num | A67995 |
|---|---|
| M. Wt | 308.42 |
| Formula | C20H24N2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1392494-64-2 |
| Synonyms | |
| SMILES | O=C(NC1=CC=CC=C1N2CCCC2)[C@H](C3=CC=CC=C3)CC |
Biological Activity
| Description | ML252 is a selective inhibitor of the KCNQ2 (Kv7.2) ion channel, exhibiting an IC50 of 69 nM for KCNQ2, along with lower inhibitory effects on KCNQ1, KCNQ2/Q3, and KCNQ4. This compound also demonstrates inhibition of key Cytochrome P450 enzymes, including CYP1A2, CYP2C9, CYP3A4, and CYP2D6, with IC50 values ranging from 3.9 nM to 19.9 nM. ML252 is notable for its ability to penetrate the blood-brain barrier, making it a valuable tool for investigating neuronal function and related disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
