Product Data Sheet
ONO-2920632
Catalog No. A67996
ONO-2920632 is an orally active TREK activator that effectively penetrates the central nervous system, exhibiting EC50 values of 0.3 µM for TREK-1 and 2.8 µM for TREK-2. This compound demonstrates significant selectivity for TREK channels over other K2P channels, showing more than 91-fold selectivity versus TASK1, TASK2, TASK3, TRAAK, and TWIK2, as well as 31-fold selectivity for TRESK. ONO-2920632 is recognized for its analgesic properties and is suitable for research applications in pain management, migraine, and various neurological disorders.
Chemical Information
| Catalog Num | A67996 |
|---|---|
| M. Wt | 354.26 |
| Formula | C15H10F4N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2230296-66-7 |
| Synonyms | VU6011887 |
| SMILES | O=C(C1=CN2C(C=C1)=NC=N2)NCC3=CC=C(OC(F)(F)F)C=C3F |
Biological Activity
| Description | ONO-2920632 is an orally active TREK activator that effectively penetrates the central nervous system, exhibiting EC50 values of 0.3 µM for TREK-1 and 2.8 µM for TREK-2. This compound demonstrates significant selectivity for TREK channels over other K2P channels, showing more than 91-fold selectivity versus TASK1, TASK2, TASK3, TRAAK, and TWIK2, as well as 31-fold selectivity for TRESK. ONO-2920632 is recognized for its analgesic properties and is suitable for research applications in pain management, migraine, and various neurological disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
