Product Data Sheet
VU0071063
Catalog No. A68005
VU0071063 is a selective activator of the Kir6.2/SUR1 potassium channel complex, exhibiting an EC50 of 7.44 μM. This compound is primarily used to study the physiological roles of Kir6.2/SUR1 in pancreatic and neuronal tissues. VU0071063 promotes hyperpolarization of β-cell membrane potential, effectively inhibiting insulin secretion. The compound’s chemotype demonstrates a pronounced structure-activity relationship, making it a valuable tool for exploring insulin signaling and regulatory mechanisms in cellular physiology.
Chemical Information
| Catalog Num | A68005 |
|---|---|
| M. Wt | 326.39 |
| Formula | C18H22N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 333415-38-6 |
| Synonyms | |
| SMILES | O=C(N1C)N(C)C2=C(N(CC3=CC=C(C(C)(C)C)C=C3)C=N2)C1=O |
Biological Activity
| Description | VU0071063 is a selective activator of the Kir6.2/SUR1 potassium channel complex, exhibiting an EC50 of 7.44 μM. This compound is primarily used to study the physiological roles of Kir6.2/SUR1 in pancreatic and neuronal tissues. VU0071063 promotes hyperpolarization of β-cell membrane potential, effectively inhibiting insulin secretion. The compound’s chemotype demonstrates a pronounced structure-activity relationship, making it a valuable tool for exploring insulin signaling and regulatory mechanisms in cellular physiology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
