Product Data Sheet
VU0546110
Catalog No. A68012
VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, exhibiting an IC50 of 1.287 μM for SLO3 in HEK293 cells and a more modest IC50 of 59.80 μM for SLO1. This compound effectively blocks both heterologous SLO3 currents and endogenous K+ currents in human sperm, leading to the cessation of sperm hyperpolarization, acrosome reaction induction, and hyper-activated motility. VU0546110 is of particular interest in reproductive biology research due to its potential contraceptive applications.
Chemical Information
| Catalog Num | A68012 |
|---|---|
| M. Wt | 461.64 |
| Formula | C24H31NO4S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1421523-00-3 |
| Synonyms | |
| SMILES | O=C(CC1=CC=C(S(=O)(C(C)C)=O)C=C1)N2CCC(CC2)CSC3=CC=C(C=C3)OC |
Biological Activity
| Description | VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, exhibiting an IC50 of 1.287 μM for SLO3 in HEK293 cells and a more modest IC50 of 59.80 μM for SLO1. This compound effectively blocks both heterologous SLO3 currents and endogenous K+ currents in human sperm, leading to the cessation of sperm hyperpolarization, acrosome reaction induction, and hyper-activated motility. VU0546110 is of particular interest in reproductive biology research due to its potential contraceptive applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
